How quickly does prednisolone work?


Prednisolone is a synthetic version of a natural corticosteroid hormone produced by the adrenal gland. They can be administered as pills, injected into a muscle or vein, injected directly into a joint, or inhaled. It is used to treat arthritis, blood disorders, immune system disorders, skin and eye conditions, respiratory diseases, cancer, and severe allergies. The most commonly given steroid pill is prednisolone. Prednisolone is usually offered in two forms: plain tablets and enteric-coated tablets. It works by reducing the immune system response to certain diseases, which helps to alleviate symptoms such as pain, swelling, and allergic responses.

How quickly does prednisolone work?

This is a rather frequent question, yet the duration for prednisolone to work depends on the route of administration, dosage and frequency. In general speaking, the peak concentrations of an immediate-release pill are reached in around 1 to 2 hours. The effects of prednisolone might be felt within a few hours. However, it may take several days to notice the full effects of prednisolone.

Oral prednisolone dosage

The initial prednisone dosage might range from 5 mg to 60 mg per day, depending on the disease entity being treated. Lower doses will often be sufficient in less severe conditions, although higher initial doses may be required in certain cases. After the initial dosage of prednisolone, the drug dosage should be kept or changed until a satisfactory reaction is observed. If there is no good clinical response after a fair period of time, prednisone should be discontinued and the patient switched to another appropriate medication. It should be remarked that dosage requirements vary and must be individualized based on the disease under treatment and the patient’s responses.

Following the observation of a satisfactory response, the favourable maintenance dosage should be determined by decreasing the initial drug dosage in modest increments at appropriate time intervals until the lowest dosage that will sustain an adequate clinical response is attained. It should be remembered that medicine dose requires continual and long-term monitoring.

Changes in clinical status due to remissions or exacerbations in the disease process, the patient’s individual drug responsiveness, and the effect of patient exposure to stressful situations unrelated to the disease entity under treatment are all examples of situations that may necessitate dosage adjustments. In the latter case, it may be essential to raise the prednisolone dosage for a period of time commensurate with the patient’s condition. If the drug is to be discontinued after long-term therapy, it is best to do so gradually. If this drug was stopped abruptly, you may experience withdrawal symptoms such as weakness, weight loss, nausea, muscle pain, headache, tiredness, dizziness. To prevent these withdrawal symptoms, gradual reduction of the dose is necessary. Withdrawal is more common if prednisolone is used for a long time or at high doses.


To avoid stomach disturbance, take prednisolone tablets by mouth with food or milk, exactly as advised by your doctor. Liquid prednisolone is available in a variety of brands, strengths, and formats as well. Read the dose directions for each product carefully because the amount of prednisolone in each medication may differ. See especially the pages on precautions and storage. Use a proper measuring device or spoon to carefully measure the dose. Do not use a regular spoon since you may not get the correct dose.


Prednisolone, or rather corticosteroids, are effective medications used in many medical conditions and as long-term disease modifications. The adverse effects and risks of taking prednisolone on the other hand are quite worrisome. Therefore, the purchase and administration of such medication strictly require a doctor prescription. Ongoing monitoring and follow-up are essential, so discuss your condition and consult the doctor in charge.